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KMID : 0370220090530010012
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Yakhak Hoeji
2009 Volume.53 No. 1 p.12 ~ p.18
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The Inhibitory Effects of Quercetin from Houttuynia cordata against Cadmium-Induced Cytotoxicity
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Choi Hwa-Jung
No Yong-Ju
Kang Jeong-Il
Baek Seung-Hwa
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Abstract
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The aim of this study was to develop antitoxic compound for cadmium-induced cytotoxic Vero cells. These cells were divided into five groups; control group (medium only), cadmium group (cadmium only), and two experimental groups. SRB (sulphorodamine B) assay was performed to evaluate the cytotoxicity of cell organelles. After cadmium was treated on Vero cells, we determined IC50 values to examine the detoxification effects of Houttuynia cordata methanol extract and quercetin under cadmium-induced cytotoxicity. Furthermore, morphological changes were observed by the light microscope. In Vero cells, methanol extract of Houttuynia cordata, and quercetin showed inhibitory effects on cadmium-induced cytotoxicity and these detoxification effects were increased in a concentration-dependent manner. These results suggest that methanol extract and quercetin from Houttuynia cordata retain a potential antitoxic activity.
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KEYWORD
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Houttuynia cordata, quercetin, cytotoxicity, cadmium, Vero cells, SRB
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